Platelets as a Novel Source of Pro-Inflammatory Chemokine CXCL14

Platelets as a Novel Source of Pro-Inflammatory Chemokine CXCL14.

OBJECTIVE Platelets are a major source of chemokines. Here, we demonstrate for the first time that platelets express significant amounts of CXCL14 and disclose powerful effects of platelet-derived CXCL14 on monocyte and endothelial migration. METHODS The expression of CXCL14 in platelets and in the supernatant of activated platelets was analysed by immunoblotting, ELISA, and flow cytometry. T...

CXCL14: the Swiss army knife chemokine.

Since their discovery in the late 1980s, chemokines have been hailed as major contributors in the recruitment and function of immune cells in health and in all types of inflammatory diseases. Expression and activity of chemokines and their receptors in cancer cells, stromal cells and tumor-associated myeloid cells have also increased the interest of targeting these molecules in cancer therapy. ...

Profiling pro-inflammatory cytokine and chemokine mRNA expression levels as a novel method for selection of increased innate immune responsiveness.

Previous studies using F1 reciprocal crosses and two parental lines of broilers show the sire is instrumental in determining the in vitro leukocyte function and cytokine/chemokine profile. Since the innate immune response is the primary means young chickens have to protect themselves, we hypothesize utilizing a novel genomics approach to select sires based on an elevated pro-inflammatory cytoki...

Developmental expression and regulation of the chemokine CXCL14 in Xenopus.

Chemokines are a family of proteins originally identified for their activity promoting the recruitment of leukocytes to inflammatory sites. Recent evidence indicates that chemokines and their receptors may also regulate key developmental processes. In this paper we report the expression and regulation of the chemokine CXCL14 during Xenopus laevis embryogenesis. CXCL14 is first detected in sever...

Conversion of Platelets from a Pro-Aggregatory to a Pro- Inflammatory Adhesive Phenotype: ROLE OF PAF IN SPATIALLY REGULATING NEUTROPHIL ADHESION AND SPREADING Running Head: Distinct Pro-Aggregatory and Pro-Inflammatory Properties of Platelets